SAT-368 CYP24A1 Mutation Masking Malignancy Mediated Hypercalcemia
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چکیده
منابع مشابه
CYP24A1 Mutation in a Girl Infant with Idiopathic Infantile Hypercalcemia
Idiopathic infantile hypercalcemia (IIH) was associated with vitamin-D supplementation in the 1950's. Fifty years later, mutations in the CYP241A gene, involved in the degradation of vitamin-D, have been identified as being a part of the etiology. We report a case of a 21-month old girl, initially hospitalized due to excessive consumption of water and behavioral difficulties. Blood tests showed...
متن کاملHypercalcemia of Malignancy
CASE STUDY A 60-year-old man initially presented with pain in the right upper quadrant in October 2010. A computed tomography (CT) scan of the abdomen pelvis completed at that time showed a mass at the junction of the body and tail of the pancreas and multiple large liver lesions. A CT-guided liver biopsy revealed low-grade neuroendocrine carcinoma. The patient was initially started on systemic...
متن کاملHumoral Hypercalcemia of Malignancy
Secretion by tumor cells of circulating bone-resorbing factors may frequently underlie the hypercalcemia that occurs in patients with malignancy. Efforts to identify the responsible mediators have been hampered by a lack of available human tumor cell systems suitable for study of the pathogenesis of the humoral hypercalcemia syndrome. We have established a transitionalcell carcinoma (TCC) line ...
متن کاملHypercalcemia of malignancy: Part II.
Oncology nurses are responsible for the ongoing assessment of hypercalcemia, including reviewing laboratory findings as well as evaluating patient symptomatology. Abnormal serum creatinine, calcium, electrolytes, magnesium, and phosphate levels and symptoms such as constipation, lethargy, and weakness may alert clinicians to problems with this oncologic emergency. Resolution of hypercalcemia is...
متن کاملHypercalcemia of malignancy: Part I.
Digital Object Identifier: 10.1188/04.CJON.209-210 Hypercalcemia is a metabolic condition that occurs when the serum calcium level rises above the normal range of 9–11 mg/dl (Myers, 2001; Smith, 2000). It is a complex metabolic oncologic emergency that can be life threatening. This column is the first of a two-part series about hypercalcemia of malignancy (HCM). Part I focuses on the pathophysi...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2020
ISSN: 2472-1972
DOI: 10.1210/jendso/bvaa046.353